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The clinical program and Phase 2b failure Phase 1 and 2a trials were successful , the peptide was safe, without significant side effects, and showed a mild lipolytic signal

Comparator Selection: Full-length hGH (to demonstrate receptor-independent effects) -adrenergic agonists (to show distinct mechanism) Vehicle control 4

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Thus, in the adipose tissue, physiological IGF-1 concentrations are not effective in stimulating changes in lipid synthesis or lipolysis, only at high concentrations is capable of stimulating glucose transport via the insulin receptor [182]